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Publications


LXR-dependent enhancer activation regulates the temporal organization of the liver's response to refeeding leading to lipogenic gene overshoot
Korenfeld, N., Gorbonos, T., Romero Florian, M.C., Rotaro, D., Goldberg, D., Radushkevitz-Frishman, T., Charni-Natan, M., Bar-Shimon, M., Cummins, C.L.* and Goldstein, I.*
PLoS Biology, 2024 || IF 7.8​
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PMID: 39241209
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Endothelial extracellular vesicles enhance vascular self-assembly in engineered human cardiac tissues
Wagner, K.T., Lu, R.X.Z., Landau, S., Shawky, S.A., Zhao, Y., Bodenstein, D.F., Jimenez Vargas, L.F., Jiang, R., Okhovatian, S., Wang, Y., Liu, C., Vosoughi, D., Gustafson, D., Fish, J.E., Cummins, C.L. and Radisic, M.
Biofabrication, 2024 || IF 8.2​
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PMID: 39226913


Cell-specific effects of insulin in a murine model of restenosis under insulin-sensitive and insulin-resistant conditions
Gonzalez Medina, M., Liu, Z., Wang, J., Zhang, C., Cash, S.B., Cummins, C.L. and Giacca, A
Cells, 2024 || IF 6​
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PMID: 39195275
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New anti-inflammatory mechanism of glucocorticoids uncovered
Cummins, C.L.*, Goldstein, I.
Trends in Endocrinology and Metabolism 2024 || IF 14.9
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PMID: 3918172
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Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms
​Landau, S., Zhao, Y., Hamidzada, H., Kent, G.K., Okhovatian, S., Lu, R.X.Z., Liu, C., Wagner, K.T., Cheung, K., Shawky, S.A., Vosoughi, D., Beroncal, E.L.,
Fernandes, I., 
Cummins, C.L., Andreazza, A.C., Keller, G.M., Epelman, S., Radisic, M.
Cell Stem Cell, 2024 || IF 14.9
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PMID: 38908380
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A novel fatty acid mimetic with pan-PPAR partial agonist activity inhibits diet-induced obesity and metabolic dysfunction-associated steatotic liver disease.
Sahin, C., Melanson, J-R., Le Billan, F.,  Magomedova, L., Ferreira, T.A.M., Oliveira, A.S., Pollock-Tahari, E., Saikali, M.F., Cash, S.B., Woo, M., Romeiro, L.A.S., Cummins, C.L.*
Molecular Metabolism, 2024 || IF 8.5
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PMID: 38763495    
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PGP-14 establishes a polar lipid permeability barrier within the C. elegans pharyngeal cuticle.
Kamal, M., Tokmakjian, L., Knox, J., Han, D., Moshiri, H., Magomedova, L., Nguyen, K.C., Zheng, H., Burns, A.R., Cooke, B., Lacoste, J., Yeo, M., Hall, D.H., Cummins, C.L., Roy, P.J.
PLoS Genetics, 2023 || IF 5.1
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PMID: 37930961
PMCID: PMC10653525     
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Regulation of Alternative Splicing by Steroid Hormones.
Le Billan, F., Umogbai, G., Cummins, C.L.*
Endocrinology, 2023 || IF 4.9
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PMID: 37226268
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Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death.
Arif, W., Mathur, B., Saikali, M.F., Chembazhi, U.V., Toohill, K., Song, Y.J., Hao, Q., Karimi, S., Blue, S.M., Yee, B.A.,
Van Nostrand, E.L., Bangru, S., Guzman, G., Yeo, G.W., Prasanth, K.V., Anakk, S., Cummins, C.L., Kalsotra, A.
Nature Communications, ​2023 || IF 16.6
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PMID: 36759613
PMCID: PMC9911759     
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The omega-3 hydroxy fatty acid 7(S)-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology.
Liu, J., Sahin, C., Ahmad, S., Magomedova, L., Zhang, M., Jia, Z., Metherel, A.H., Orellana, A., Poda, G., Bazinet, R.P.,
Attisano, L., Cummins C.L., Peng, H., Krause H.M.
Science Signalling, ​2022 || IF 9.1
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PMID: 35857636
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Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions.
Li. J.-X. and Cummins, C.L.*
Nature Reviews Endocrinology, 2022 || IF 43.3
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PMID: 35585199​
PMCID: PMC9116713
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AKR1D1 knockout mice develop a sex dependent metabolic phenotype.
Gathercole, L.L., Nikolaou, N., Harris, S.E., Arvaniti, A., Poolman, T.M., Hazlehurst, J.M., Kratschmar, D.V., Todorčević, M., Moolla, A., Dempster, N., Pink, R.C., Saikali, M.F., Bentley, L., Penning, T.M., Ohlsson, C., Cummins, C.L., Poutanen, M., Odermatt, A., Cox, R.D., and Tomlinson, J.W. 
Journal of Endocrinology​, 2022 || IF 4.3
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PMID: 35318963
PMCID: PMC9086936​
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Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.
Dotan, I., Yang, J., Ikeda, J., Roth, Z., Pollock-Tahiri, E., Desai, H., Sivasubramaniyam, T., Rehal, S., Rapps, J., Li, Y.Z., Le, H., Farber, G., Alchami, E., Xiao, C., Karim, S., Gronda, M., Saikali, M.F., Tirosh, A., Wagner, K.U., Genest, J., Schimmer, A.D., Gupta, V., Minden, M.D., Cummins, C.L., Lewis, G.F., Robbins, C., Jongstra-Bilen, J., Cybulsky, M. and Woo, M. 
Communications Biology, 2022 || IF 5.5
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PMID: 35169231
PMCID: PMC8847578
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Phenolic lipids derived from cashew nut shell liquid to treat metabolic diseases.
Sahin, C., Magomedova,L., Ferreira, T.A.M., Liu, J, Tiefenbach, J., Alves, P.S., Queiroz, F.J.G., de Oliveira, A. S., Bhattacharyya, M., Grouleff, J, Nogueira, P.C.N., Silveira, E.R., Moreira, D.C., Leite, J.R.S.A., Brand, G.D., Uehling, D., Poda, G., Krause, H., Cummins, C.L.*, and Romeiro, L.A.S.* 
Journal of Medicinal Chemistry, 2021 || IF 7.4
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PMID: 35089724​
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4-Phenylbutyric acid improves free fatty acid-induced hepatic insulin resistance in vivo.
Pereira, S., Moore, J., Li, J.X., Yu, W.Q., Zhang, L., Ghanim, H., Paresh, D., Volchuk, A., Cummins, C.L., Tsiani, E., and Giacca, A. 
Endocrine Connections, 2021 || IF 3.3
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PMID: 34319253
PMCID: PMC8346193
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Activation and gut-homing of peripheral T cells in HIV immunologic non-responders desite long term viral suppression.
Rousseau, R., Szadkowski, L., Kovacs, C., Saikali, M.F., Nadeem, R., Malazogu, F., Huibner, S., Cummins, C.L., Kaul, R., and Walmsley, S.L. 
PLOS One, 2021 || IF 3.2
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PMID: 34320023
PMCID: PMC8318285​
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Exploring the transformability of polymer-lipid hybrid nanoparticles and nanomaterial-biology interplay to facilitate tumor penetration, cellular uptake and intracellular targeting of anticancer drugs. 
Amini, M.A., Ahmed, T., Liu, F.F., Abbasi, A.Z., Soeandy, C.D., Zhang, R.X., Prashad, P., Cummins, C.L., Rauth, A.M., Henderson, J.T., and Wu, X.Y. 
Expert Opinion on Drug Delivery, 2021 || IF 4.8
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PMID: 33703991
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The secretome of liver x receptor agonist-treated early outgrowth cells decreases atherosclerosis in Ldlr-/- mice. 
Rasheed, A., Shawky, S.A., Tsai, R., Jung, R. G., Simard, T., Saikali, M.F., Hibbert, B., Rayner, K.J and Cummins, C. L.* 
Stem Cells Translational Medicine, 2021 || IF 6.4
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PMID: 33231376
PMCID: PMC7900590​
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Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output.
Lin, L. Metherel, A.H., Di Miceli, M., Liu, Z., Sahin, C., Fioramonti, X., Cummins, C.L., Layé, S., and Bazinet, R.P. 
Journal of Lipid Research, 2020 || IF 4.5
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PMID: 32826272
PMCID: PMC7604729​
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Selective peroxisome proliferator-activated receptor-gamma modulator, INT131 exhibits anti-inflammatory effects in an EcoHIV mouse model.
Omeragic, A., Saikali, M.F., Currier, S., Volsky, D.J., Cummins, C.L. and Bendayan, R. 
FASEB Journal, 2020 || IF 5.5
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PMID: 31907999
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Essential role of STAT-3 dependent NF-ĸB activation on IL-6-mediated downregulation of hepatic transporters. 
Abualsunun, W.A., Sahin, C., Cummins, C.L., and Piquette-Miller, M. 
European Journal of Pharmaceutical Sciences, 2020 || IF 3.5
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PMID: 31740392
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The marginal cells of the Caenorhabditis elegans pharynx scavenge cholesterol and other hydrophobic small molecules. 
Kamal, M., Moshiri, H., Magomedova, L., Han, D., Nguyen, K.C.Q., Yeo, M., Knox, J., Bagg, R., Won, A.M., Szlapa, K., Yip, C.M., Cummins, C.L., Hall, D.H., and Roy, P.J. 
Nature Communications, 2019 || IF 11.9
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PMID: 31477732
PMCID: PMC6718421​
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Peroxisome Proliferator-Activated Receptor-gamma agonists exhibit anti-inflammatory and antiviral effects in an EcoHIV mouse model.
Omeragic, A., Kara-Yacoubian, N., Kelschenbach, J., Sahin, C., Cummins, C.L., Volsky, D. and Bendayan, R. 
Scientific Reports, 2019 || IF 4.1
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PMID: 31263138
PMCID: PMC6603270​
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A miR-29a-driven negative feedback loop regulates peripheral glucocorticoid receptor signaling. 
Glantschnig, C., Koenen, M., Lozano, M.G., Karbiener, M., Pickrahn, I., Williams-Dautovich, J., Patel, R., Cummins, C.L., Giroud, M., Hartleben, G., Vogl, E., Blüher, M., Tuckermann, J., Uhlenhaut, H., Herzig, S., Scheideler, M.
FASEB Journal, 2019 || IF 5.5
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PMID: 30742779
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ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development. 
Magomedova, L., Tiefenbach, J., Zilberman, E., Le Billan, F., Voisin, V., Saikali, M., Boivin, V., Robitaille, M., Gueroussov, S. Irimia, M., Ray, D., Patel, R., Xu, C, Jeyasuria, P., Bader, G.D., Hughes, T.R., Morris, Q.D., Scott, M.S., Krause, H., Angers, S., Blencowe, B.J., and Cummins, C.L.*
Nucleic Acids Research, 2019 || IF 11.6
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PMID: 30698747
PMCID: PMC6451108​
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3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) prevents high fat diet-induced insulin resistance via maintenance of hepatic lipid homeostasis.
Mohan, H., Brandt, S.L., Kim, J.H., Wong, F., Lai, M., Prentice, K.J., Al Rijjal, D., Magomedova, L., Batchuluun, B., Burdett, E., Bhattacharjee, A., Cummins, C.L., Belsham, D.D., Cox, B., Liu, Y., Wheeler, M.B. 
Diabetes, Obesity and Metabolism, 2019 || IF 6.0
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PMID: 30062833
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Mammalian susceptibility to a neonicotinoid insecticide after fetal and early postnatal exposure. 
Burke, A.P., Niibori, Y., Terayama, H., Ito, M., Pidgeon, C., Arsenault, J., Camarero, P.R., Cummins, C.L., Mateo, R., Sakabe, K., Hampson, D.R. 
Scientific Reports, 2018 || IF 4.1
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PMID: 30413779
PMCID: PMC6226530​
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Beyond the foam cell: the role of LXRs in preventing atherogenesis. 
Rasheed, A., and Cummins, C.L.* 
​International Journal of Molecular Sciences, 2018 || IF 5.9
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PMID: 30087224
PMCID: PMC6121590​
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Strategies and limitations associated with in vitro characterization of vitamin D receptor activators. 
Bukuroshi, P., Saitoh, H., Magomedova, L., Cummins, C.L., Chow, E.C., Li, A.P. and Pang, K.S. 
Biochemical Pharmacology, 2018 || IF 4.2
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PMID: 30028992
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Idebenone and CoQ10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases.
Tiefenbach, J., Magomedova, L., Liu, J., Reunov, A.A., Tsai, R., Eappen, N.S., Jockusch, R., Nislow, C., Cummins, C.L. and Krause, H.
Disease Model Mechanisms, 2018 || IF 4.7
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PMID: 30171034
PMCID: PMC6177011​
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Loss of the liver x receptors disrupts the balance of hematopoietic populations, with detrimental effects on endothelial progenitor cells.
Rasheed, A., Tsai, R., and Cummins, C.L.* 
Journal of the American Heart Association, 2018 || IF 5.1
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PMID: 29739800
PMCID: PMC6015321​
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Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control
Jongstra-Bilen, J., Zhang, C.X., Wisnicki, T., Li, M.K., Alfred-White, S., Ilaalagan, R., Ferri, D.M., Deonarain, A., Wan, M.H., Hyduk, S.J., Cummins, C.L. and Cybulsky, M.I. 
The Journal of Immunology, 2017 || IF 4.9
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PMID: 28784845
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Getting the skinny on follistatin and fat. 
Li, J.X. and Cummins, C.L.* 
Endocrinology, 2017 || IF 4.3
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PMID: 28609834
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The CRH-transgenic Cushingoid mouse is a model of glucocorticoid-induced osteoporosis. 
Williams-Dautovich, J., Yogendirarajah, K., dela Cruz, A., Patel, R., Tsai, R., Mitchell, J., Grynpas, M.A., and Cummins, C.L.* 
JBMR Plus, 2017
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PMID: 30283880
PMCID: PMC6124163
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Subchronic glucocorticoids, glutathione depletion and a postpartum model elevate monoamine oxidase a activity in the prefrontal cortex of rats. 
Raitsin, S., Tong, J., Kish, S., Xu, X., Magomedova, L., Cummins, C., Andreazza, A.C., Scola, G., Baker, G., Meyer, J.H. 
Brain Research, 2017 || IF 2.7
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PMID: 28435083
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Separating the anti-inflammatory and diabetogenic effects of glucocorticoids through LXRβ antagonism.
Patel, R., Magomedova, L., Tsai, R., Angers, S., Orellana, A. and Cummins, C.L.* 
Endocrinology, 2017 || IF 4.3
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PMID: 28324010
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Multilayered control of alternative splicing regulatory networks by transcription factors. 
Han, H., Braunschweig, U., Gonatopoulos-Pournatzis, T., Weatheritt, R.J., Hirsch, C.L., Ha, K.C., Radovani, E., Nabeel-Shah, S., Sterne-Weiler, T., Wang, J., O’Hanlon, D., Pan, Q., Ray, D., Zheng, H., Vizeacoumar, F., Datti, A, Magomedova, L., Cummins, C.L., Hughes, T. R., Greenblatt, J.F., Wrana, J.L., Moffat, J. and Blencowe, B.J. 
Molecular Cell, 2017 || IF 14
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PMID: 28157508
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Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice.
Zeng, K., Tian, L., Patel, R, Shao, W., Song, Z., Liu, L., Manuel, J., Ma, M., McGilvray, I., Cummins, C.L., Weng, J., Jin, T. 
Endocrinology, 2016 || IF 4.3
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PMID: 27967217
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Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.
Bashiri, A., Nesan D., Tavallaee, G., Sue-Chue-Lam, I., Chien, K., Maguire, G.F., Naples, M., Zhang, J., Magomedova, L., Adeli, K., Cummins, C.L., and Ng, D.S. 
Biochimica et Biophysica Acta, 2016 || IF 5.2
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PMID: 27090939
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EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function. 
Huroy, S., Kanawaty, A., Magomedova, L., Cummins, C.L., George, S.R., van der Kooy,, D., and Henderson, J.T. 
Behavioural Brain Research, 2016 || IF 3.0
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PMID: 26408450
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Loss of the mono-ADP-ribosyltransferase, Tiparp, increases sensitivity to dioxin-induced steatohepatitis and lethality.
Ahmed, S., Bott, D., Gomez, A., Tamblyn, L., Rasheed, A., Cho, T., MacPherson, L., Sugamori, K.S., Yang, Y., Grant, D.M., Cummins, C.L., and Matthews, J. 
Journal of Biological Chemistry, 2015 || IF 4.7
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PMID: 25975270
PMCID: PMC4505429
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SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes.
Gilbert, R.E., Thai, K., Advani, S.L., Cummins, C.L., Kepecs, D.M., Schroer, S.A., Woo, M., Zhang, Y. 
Diabetologia, 2015 || IF 6.5
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PMID: 25563725
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Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. 
Patel, R.†, Bookout, A.†, Magomedova, L., Owen, B.M., Consiglio, G.P., Shimizu, M., Zhang, Y., Mangelsdorf, D.J., Kliewer, S.A. and Cummins, C.L.*
​
†contributed equally
Molecular Endocrinology, 2015 || IF 4.8
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PMID: 25495872
PMCID: PMC4318881
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Minireview: new molecular mediators of glucocorticoid receptor activity in metabolic tissues. 
Patel, R., Williams-Dautovich, J. and Cummins, C. L.* 
Molecular Endocrinology, 2014 || IF 4.8
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PMID: 24766141
PMCID: PMC5414825
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The cellular response to small molecules is defined by biological and structural chemogenomic signatures.
Lee, A.Y., St. Onge, R.P., Wallace, I.M., Heisler, L.E. Surendra, A. Fung, E., Spagnuolo, P.A., Jitkova, Y., Gronda, M., Wu, Y. Urbanus, M., Gebbia, M., Proctor, M., Cheung-Ong, K., Torres, N., Lissina, E., Miranda, M., Schlecht, U., Suresh, S., Aparicio, A.M., Han, MK, Spear, E.D., Nile, A.H., Duby, G., Zeghouf, M., Kim, M.K., Davis, R.W., Kaiser, C.A., Trimble, W.S., Boutry, M., Cherfils, J., Cummins, C.L., Brown, G.W., Schimmer, A.D., Bankaitis, V.A., Nislow, C., Bader, G.D., Giaever, G.
Science, 2014 || IF 31.0
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PMID: 24723613
PMCID: PMC4254748
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Liver X receptors preserve renal glomerular integrity under normoglycemia and in diabetes in mice. 
Patel, M., Wang, X.X., Magomedova, L., John, R., Rasheed, A., Santamaria, H., Wang, W., Tsai, R., Qiu, L., Orellana, A., Advani, A., Levi, M., and Cummins, C.L.* 
Diabetologia, 2014 || IF 6.5
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PMID: 24201575
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Vitamin D receptor activation down-regulates the small heterodimer partner and increases Cyp7a1 to lower cholesterol. 
Chow, E.C., Magomedova, L., Quach, H.P‡, Patel, R.‡, Durk, M.R., Fan, J., Maeng, H.J. Irondi, K., Anakk, S., Moore, D.D., Cummins, C.L.† and Pang, K.S.†  
​†, ‡ contributed equally
Gastroenterology, 2014 || IF 12.8
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PMID: 24365583
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Induction of p-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells. 
Chan, G.N., Patel, R., Cummins, C.L. and Bendayan, R.B. 
Antimicrobial Agents and Chemotherapy, 2013 || IF 4.6
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PMID: 23836171
PMCID: PMC3754350
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Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin-Induced Diabetes
​Hazra, S. ‡, Rasheed, A. ‡, Bhatwadekar, A, Wang, X., Yan, Y., Patel, M., Caballero, S., Magomedova, L., Solis, N., Thinschmidt, J., Verma, A., Li, Q., Levi, M., Cummins, C.L.*, and Grant, M.B.* 
‡ contributed equally; *co-corresponding authors
Diabetes, 2012 || IF 7.9
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PMID: 22891211
PMCID: PMC3501845
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A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
Wollam J., Magner, D.B., Magomedova, L., Rass, E., Shen,Y., Rottiers,V., Habermann, B., Cummins, C.L. and Antebi, A.
PLOS Biology, 2012 || IF 12.7
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PMID: 22505847
PMCID: PMC3323522
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Lecithin:cholesterol acetyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice. 
Hager, L., Li L., Pun, H., Liu, L., Hossain, M.A., Maguire, G.F., Naples, M., Baker, C., Magomedova, L., Tam, J., Adeli, K., Cummins, C.L., Connelly P.W., and Ng, D.S. 
Journal of Biological Chemistry, 2012 || IF 4.7
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PMID: 22500017
PMCID:  PMC3370258​​
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Dafadine inhibits DAF-9 to promote dauer-formation and longevity of Caenorhabditis elegans. 
Luciani, G.M., Magomedova, L., Puckrin, R., Urbanus, M.L., Wallace, I.M., Giaever, G., Nislow, C., Cummins, C. L.* and Roy, P.J.* 
Nature Chemical Biology, 2011 || IF 12.9
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PMID: 22057127
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Compound prioritization methods increase rates of chemical probe discovery in model organisms. 
Wallace, I.M., Urbanus, M.L., Luciani, G.M., Burns, A.R., Han, M., Wang, H., Arora, K. Heisler, L.E., Proctor, M., St. Onge, R.P., Roemer, T., Roy, P.J., Cummins, C.L., Bader, G.D., Nislow, C., Giaver, G. 
Chemistry & Biology, 2011 || IF 6.2
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PMID: 22035796
PMCID: PMC4193902​​
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The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.  
Wollam, J., Magomedova, L., Magner, D.B., Shen, Y., Rottiers, V., Motola, D.L., Mangelsdorf, D.J., Cummins, C.L., and Antebi, A. 
Aging Cell, 2011 || IF 5.7
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PMID: 21749634
PMCID: PMC3909771
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1Alpha,25-Dihydroxyvitamin D3 upregulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo. 
Chow, E.C., Durk, M.R., Cummins, C.L., Pang, K.S. 
Journal of Pharmacology and Experimental Therapeutics, 2011 || 3.9
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PMID: 21421739


Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells.
Chan, G.N., Hoque, M.T., Cummins, C.L., Bendayan, R. 
Journal of Neurochemistry, 2011 || IF 4.0
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PMID: 21517853
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LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. 
Patel, R., Patel, M., Tsai, R., Lin, V., Bookout, A.L., Zhang, Y., Magomedova, L., Li, T., Chan, J.F., Budd, C., Mangelsdorf, D.J., and Cummins, C.L.* 
Journal of Clinical Investigation, 2011 || 12.8
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PMID:  21123945
PMCID: PMC3007136​​
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AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids.
Schmidt, D.R., Schmidt, S., Holmstrom, S.R., Makishima, M., Yu, R.T., Cummins C.L., Mangelsdorf D.J., Kliewer, S.A. 
Journal of Biological Chemistry, 2011 || IF 4.7
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PMID: 21081494
PMCID: PMC3024736​​
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Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. 
Gottschalk, S., Cummins, C.L., Leibfritz, D., Christians, U., Benet, L.Z., Serkova, N.J. 
Neurotoxicology, 2011 || IF 2.7
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PMID: 21075140 ​​
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Liver X receptors as therapeutic targets for managing cholesterol: Implications for atherosclerosis and other inflammatory conditions. 
Zhang, Y., Chan, J.F. and Cummins, C. L.* 
Journal of Clinical Lipidology, 2009 || IF 0.9
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PMID: 20852746
PMCID: PMC2941513​​
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Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. 
Sharma, K. K., Wang, Z., Motola, D. L., Cummins, C. L., Mangelsdorf, D. J., and Auchus, R. J. 
Molecular Endocrinology, 2009 || IF 4.8
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PMID: 19196833
PMCID: PMC2675950     
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Identification and quantitation of sorbitol-based nuclear clarifying agents extracted from common laboratory and consumer plasticware made of polypropylene. 
McDonald, J. G., Cummins, C. L., Barkley, R. M., Thompson, B. M. and Lincoln, H. A.
Analytical Chemistry, 2008 || IF 5.7
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PMID: 18533681
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PMCID: PMC2727714     
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Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. 
Lee, Y.K., Schmidt, D. R., Cummins, C. L., Choi, M., Peng, L., Zhang, Y., Goodwin, B., Hammer, R.E., Mangelsdorf, D. J. and Kliewer, S. A.  
​Molecular Endocrinology, 2008 || IF 4.8
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PMID: 18323469
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PMCID: ​PMC2409274     
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Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. 
Katona, B. W., Cummins, C. L., Ferguson, A. D., Li, T., Schmidt, D. R., Mangelsdorf, D. J. and Covey, D. F. 
Journal of Medicinal Chemistry, 2007 || IF 5.6
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PMID: 17963371
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27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. 
Umetani, M., Domoto, H., Gormley, A. K., Yuhanna, I.S., Cummins, C. L., Javitt, N. B., Korach, K. S., Shaul, P. W., Mangelsdorf, D. J. 
Nature Medicine, 2007 || IF 24.3
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PMID: 17873880
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Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice. 
Oz, O. K., Hajibeigi, A., Howard, K., Cummins, C. L., van Abel, M., Bindels, R. J., Word, R. A., Kuro-o, M., Pak, C. Y. and Zerwekh, J. E. 
Journal of Bone and Mineral Research, 2007 || IF 6.1
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PMID: 17708714 ​​
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In vivo imaging of FXR activity reveals the ileum as the primary bile acid signaling tissue. 
Houten, S. M., Volle, D. H., Cummins, C. L., Mangelsdorf, D. J. and Auwerx, J. 
Molecular Endocrinology, 2007 || IF 4.8
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PMID: 17426284
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A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. 
Gerisch, B., Rottiers, V., Li, D., Motola, D. L., Cummins, C. L., Lehrach, H., Mangelsdorf, D. J., and Antebi, A. 
Proceedings of the National Academy of Sciences of the United States of America, 2007 || IF 9.7
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PMID: 17360327
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PMCID: PMC1821127      ​​
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The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice. 
Volle, D. H., Duggavathi, R., Magnier, B. C., Houten, S. M., Cummins, C. L., Lobaccaro, J. M., Verhoeven, G., Schoonjans, K., and Auwerx, J. 
Genes & Development, 2007 || IF 12.4
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PMID: 17289919
PMCID: PMC1785120     
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Liver X receptors regulate adrenal cholesterol balance. 
Cummins, C. L.‡, Volle, D. H. ‡, Zhang, Y., McDonald, J. G., Sion, B., Lefrancois-Martinez, A.-M., Caira F., Veyssiere, G., Mangelsdorf, D. J. † and Lobaccaro, J. M. † 
‡,†contributed equally. 
Journal of Clinical Investigation, 2006 || IF 12.8
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PMID: 16823488
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PMCID: PMC1483175     
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Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. 
Rottiers, V. , Motola, D. L., Gerisch, B., Cummins, C. L., Nishiwaki, K., Mangelsdorf, D. J., and Antebi, A. 
Developmental Cell, 2006 || IF 12.8
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PMID: 16563875 ​​
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Liver X receptors and cholesterol homeostasis: spotlight on the adrenal gland. 
Cummins, C. L.* and Mangelsdorf, D. J. 
Biochemical Society Transactions, 2006 || IF 2.6
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PMID: 17073762
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Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. 
Motola, D. L., Cummins, C. L., Rottiers, V., Sharma, K. K., Li, T., Li, Y., Suino-Powell, K., Xu, H. E., Auchus, R. J., Antebi, A., and Mangelsdorf, D. J. 
Cell, 2006 || IF 32.0
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PMID: 16529801​​
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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., Gerard, R. D., Repa, J. J., Mangelsdorf, D. J. and Kliewer, S. A. 
​Cell Metabolism, 2005 || IF 14.6
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PMID: 16213224
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Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. 
Benet, L. Z., Cummins, C. L., and Wu, C.-Y. 
​International Journal of Pharmaceutics, 2004 || IF 3.5
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PMID: 15158963 ​​
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Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRα (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. 
Volle, D. H., Repa, J. J., Mazur, A., Cummins, C. L., Val, P., Henry-Berger, J., Caira, F., Veyssiere, G., Mangelsdorf, D. J., and Lobacarro, J. M. 
Molecular Endocrinology, 2004 || IF 4.8
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PMID: 14739254 ​​
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CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.  
Cummins, C. L., Jacobsen, W., Christians U., and Benet, L.Z. 
Journal of Pharmacology and Experimental Therapeutics, 2004 || IF 3.9
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PMID: 14569063 ​​


In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: Studies using the rat single-pass intestinal perfusion model.
Cummins, C. L.
, Salphati, L., Reid, M.J and Benet, L.Z. 
​Journal of Pharmacology and Experimental Therapeutics, 2003 || IF 3.9
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PMID: 12649383


Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. 
Benet L. Z., Cummins, C. L. and Wu, C.-Y. 
Current Drug Metabolism, 2003 || IF 4.4
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PMID: 14529371​​

Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). 
Unger, M., Holzgrabe, U., Jacobsen, W., Cummins, C. and Benet, L.Z
Planta Medica, 2002 || IF 2.3
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PMID: 12494328​​
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Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein.
Cummins, C. L., Wu, C.-Y. and Benet, L. Z. 
Clinical Pharmacology & Therapeutics, 2002 || IF 6.8
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PMID: 12426511
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Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. 
Cummins, C. L., Jacobsen, W. and Benet, L. Z. 
Journal of Pharmacology and Experimental Therapeutics, 2002 || IF 3.9
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PMID: 11861813 ​​

Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).
Flanagan, S. D., Cummins, C. L., Susanto, M., Liu, X., Takahashi, L. H., and Benet, L. Z. 
Pharmacology, 2002 || IF 1.6
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PMID: 11834888​​

The drug-efflux metabolism alliance:  biochemical aspects.
Benet, L. Z. and Cummins, C. L.  
Advanced Drug Delivery Reviews, 2001 || IF 12.9
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PMID: 11576692
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Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1 and MRP2) in CYP3A4-transfected caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.  
Cummins, C. L., Mangravite, L. M. and Benet, L. Z.  
Pharmaceutical Research, 2001 || IF 4.7
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PMID: 11587480​​

Determination of p-aminosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity.
Cummins, C. L., O’Neil, W. M., Soo, E. C., Lloyd, D. K., and Wainer, I. W. 
Journal of Chromatography B, 1997 || IF 2.5
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PMID: 9342682

Leslie Dan Faculty of Pharmacy

Cummins Laboratory
144 College St. Rm 1140
Toronto, ON M5S 3M2
(416) 978-6146

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