Publications
Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions.
Li. J.-X. and Cummins, C.L. Nature Reviews Endocrinology, 2022 || IF 43.3 |
AKR1D1 knockout mice develop a sex dependent metabolic phenotype.
Gathercole, L.L., Nikolaou, N., Harris, S.E., Arvaniti, A., Poolman, T.M., Hazlehurst, J.M., Kratschmar, D.V., Todorčević, M., Moolla, A., Dempster, N., Pink, R.C., Saikali, M.F., Bentley, L., Penning, T.M., Ohlsson, C., Cummins, C.L., Poutanen, M., Odermatt, A., Cox, R.D., and Tomlinson, J.W. Journal of Endocrinology, 2022 || IF 4.3 |
Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.
Dotan, I., Yang, J., Ikeda, J., Roth, Z., Pollock-Tahiri, E., Desai, H., Sivasubramaniyam, T., Rehal, S., Rapps, J., Li, Y.Z., Le, H., Farber, G., Alchami, E., Xiao, C., Karim, S., Gronda, M., Saikali, M.F., Tirosh, A., Wagner, K.U., Genest, J., Schimmer, A.D., Gupta, V., Minden, M.D., Cummins, C.L., Lewis, G.F., Robbins, C., Jongstra-Bilen, J., Cybulsky, M. and Woo, M. Communications Biology, 2022 || IF 5.5 |
Phenolic lipids derived from cashew nut shell liquid to treat metabolic diseases.
Sahin, C., Magomedova,L., Ferreira, T.A.M., Liu, J, Tiefenbach, J., Alves, P.S., Queiroz, F.J.G., de Oliveira, A. S., Bhattacharyya, M., Grouleff, J, Nogueira, P.C.N., Silveira, E.R., Moreira, D.C., Leite, J.R.S.A., Brand, G.D., Uehling, D., Poda, G., Krause, H., Cummins, C.L.*, and Romeiro, L.A.S.* Journal of Medicinal Chemistry, 2021 || IF 7.4 |
4-Phenylbutyric acid improves free fatty acid-induced hepatic insulin resistance in vivo.
Pereira, S., Moore, J., Li, J.X., Yu, W.Q., Zhang, L., Ghanim, H., Paresh, D., Volchuk, A., Cummins, C.L., Tsiani, E., and Giacca, A. Endocrine Connections, 2021 || IF 3.3 |
Activation and gut-homing of peripheral T cells in HIV immunologic non-responders desite long term viral suppression.
Rousseau, R., Szadkowski, L., Kovacs, C., Saikali, M.F., Nadeem, R., Malazogu, F., Huibner, S., Cummins, C.L., Kaul, R., and Walmsley, S.L. PLOS One, 2021 || IF 3.2 |
Exploring the transformability of polymer-lipid hybrid nanoparticles and nanomaterial-biology interplay to facilitate tumor penetration, cellular uptake and intracellular targeting of anticancer drugs.
Amini, M.A., Ahmed, T., Liu, F.F., Abbasi, A.Z., Soeandy, C.D., Zhang, R.X., Prashad, P., Cummins, C.L., Rauth, A.M., Henderson, J.T., and Wu, X.Y. Expert Opinion on Drug Delivery, 2021 || IF 4.8 |
The secretome of liver x receptor agonist-treated early outgrowth cells decreases atherosclerosis in Ldlr-/- mice.
Rasheed, A., Shawky, S.A., Tsai, R., Jung, R. G., Simard, T., Saikali, M.F., Hibbert, B., Rayner, K.J and Cummins, C. L.* Stem Cells Translational Medicine, 2021 || IF 6.4 |
Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output.
Lin, L. Metherel, A.H., Di Miceli, M., Liu, Z., Sahin, C., Fioramonti, X., Cummins, C.L., Layé, S., and Bazinet, R.P. Journal of Lipid Research, 2020 || IF 4.5 |
Selective peroxisome proliferator-activated receptor-gamma modulator, INT131 exhibits anti-inflammatory effects in an EcoHIV mouse model.
Omeragic, A., Saikali, M.F., Currier, S., Volsky, D.J., Cummins, C.L. and Bendayan, R. FASEB Journal, 2020 || IF 5.5 |
The marginal cells of the Caenorhabditis elegans pharynx scavenge cholesterol and other hydrophobic small molecules.
Kamal, M., Moshiri, H., Magomedova, L., Han, D., Nguyen, K.C.Q., Yeo, M., Knox, J., Bagg, R., Won, A.M., Szlapa, K., Yip, C.M., Cummins, C.L., Hall, D.H., and Roy, P.J. Nature Communications, 2019 || IF 11.9 |
Peroxisome Proliferator-Activated Receptor-gamma agonists exhibit anti-inflammatory and antiviral effects in an EcoHIV mouse model.
Omeragic, A., Kara-Yacoubian, N., Kelschenbach, J., Sahin, C., Cummins, C.L., Volsky, D. and Bendayan, R. Scientific Reports, 2019 || IF 4.1 |
A miR-29a-driven negative feedback loop regulates peripheral glucocorticoid receptor signaling.
Glantschnig, C., Koenen, M., Lozano, M.G., Karbiener, M., Pickrahn, I., Williams-Dautovich, J., Patel, R., Cummins, C.L., Giroud, M., Hartleben, G., Vogl, E., Blüher, M., Tuckermann, J., Uhlenhaut, H., Herzig, S., Scheideler, M. FASEB Journal, 2019 || IF 5.5 |
ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development.
Magomedova, L., Tiefenbach, J., Zilberman, E., Le Billan, F., Voisin, V., Saikali, M., Boivin, V., Robitaille, M., Gueroussov, S. Irimia, M., Ray, D., Patel, R., Xu, C, Jeyasuria, P., Bader, G.D., Hughes, T.R., Morris, Q.D., Scott, M.S., Krause, H., Angers, S., Blencowe, B.J., and Cummins, C.L.* Nucleic Acids Research, 2019 || IF 11.6 |
3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) prevents high fat diet-induced insulin resistance via maintenance of hepatic lipid homeostasis.
Mohan, H., Brandt, S.L., Kim, J.H., Wong, F., Lai, M., Prentice, K.J., Al Rijjal, D., Magomedova, L., Batchuluun, B., Burdett, E., Bhattacharjee, A., Cummins, C.L., Belsham, D.D., Cox, B., Liu, Y., Wheeler, M.B. Diabetes, Obesity and Metabolism, 2019 || IF 6.0 |
Mammalian susceptibility to a neonicotinoid insecticide after fetal and early postnatal exposure.
Burke, A.P., Niibori, Y., Terayama, H., Ito, M., Pidgeon, C., Arsenault, J., Camarero, P.R., Cummins, C.L., Mateo, R., Sakabe, K., Hampson, D.R. Scientific Reports, 2018 || IF 4.1 |
Beyond the foam cell: the role of LXRs in preventing atherogenesis.
Rasheed, A., and Cummins, C.L.* International Journal of Molecular Sciences, 2018 || IF 5.9 |
Idebenone and CoQ10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases.
Tiefenbach, J., Magomedova, L., Liu, J., Reunov, A.A., Tsai, R., Eappen, N.S., Jockusch, R., Nislow, C., Cummins, C.L. and Krause, H. Disease Model Mechanisms, 2018 || IF 4.7 |
Loss of the liver x receptors disrupts the balance of hematopoietic populations, with detrimental effects on endothelial progenitor cells.
Rasheed, A., Tsai, R., and Cummins, C.L.* Journal of the American Heart Association, 2018 || IF 5.1 |
Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control
Jongstra-Bilen, J., Zhang, C.X., Wisnicki, T., Li, M.K., Alfred-White, S., Ilaalagan, R., Ferri, D.M., Deonarain, A., Wan, M.H., Hyduk, S.J., Cummins, C.L. and Cybulsky, M.I. The Journal of Immunology, 2017 || IF 4.9 |
The CRH-transgenic Cushingoid mouse is a model of glucocorticoid-induced osteoporosis.
Williams-Dautovich, J., Yogendirarajah, K., dela Cruz, A., Patel, R., Tsai, R., Mitchell, J., Grynpas, M.A., and Cummins, C.L.* JBMR Plus, 2017 |
Subchronic glucocorticoids, glutathione depletion and a postpartum model elevate monoamine oxidase a activity in the prefrontal cortex of rats.
Raitsin, S., Tong, J., Kish, S., Xu, X., Magomedova, L., Cummins, C., Andreazza, A.C., Scola, G., Baker, G., Meyer, J.H. Brain Research, 2017 || IF 2.7 |
Multilayered control of alternative splicing regulatory networks by transcription factors.
Han, H., Braunschweig, U., Gonatopoulos-Pournatzis, T., Weatheritt, R.J., Hirsch, C.L., Ha, K.C., Radovani, E., Nabeel-Shah, S., Sterne-Weiler, T., Wang, J., O’Hanlon, D., Pan, Q., Ray, D., Zheng, H., Vizeacoumar, F., Datti, A, Magomedova, L., Cummins, C.L., Hughes, T. R., Greenblatt, J.F., Wrana, J.L., Moffat, J. and Blencowe, B.J. Molecular Cell, 2017 || IF 14 |
Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice.
Zeng, K., Tian, L., Patel, R, Shao, W., Song, Z., Liu, L., Manuel, J., Ma, M., McGilvray, I., Cummins, C.L., Weng, J., Jin, T. Endocrinology, 2016 || IF 4.3 |
Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.
Bashiri, A., Nesan D., Tavallaee, G., Sue-Chue-Lam, I., Chien, K., Maguire, G.F., Naples, M., Zhang, J., Magomedova, L., Adeli, K., Cummins, C.L., and Ng, D.S. Biochimica et Biophysica Acta, 2016 || IF 5.2 |
Loss of the mono-ADP-ribosyltransferase, Tiparp, increases sensitivity to dioxin-induced steatohepatitis and lethality.
Ahmed, S., Bott, D., Gomez, A., Tamblyn, L., Rasheed, A., Cho, T., MacPherson, L., Sugamori, K.S., Yang, Y., Grant, D.M., Cummins, C.L., and Matthews, J. Journal of Biological Chemistry, 2015 || IF 4.7 |
Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.
Patel, R.†, Bookout, A.†, Magomedova, L., Owen, B.M., Consiglio, G.P., Shimizu, M., Zhang, Y., Mangelsdorf, D.J., Kliewer, S.A. and Cummins, C.L.* †contributed equally Molecular Endocrinology, 2015 || IF 4.8 |
Minireview: new molecular mediators of glucocorticoid receptor activity in metabolic tissues.
Patel, R., Williams-Dautovich, J. and Cummins, C. L.* Molecular Endocrinology, 2014 || IF 4.8 |
The cellular response to small molecules is defined by biological and structural chemogenomic signatures.
Lee, A.Y., St. Onge, R.P., Wallace, I.M., Heisler, L.E. Surendra, A. Fung, E., Spagnuolo, P.A., Jitkova, Y., Gronda, M., Wu, Y. Urbanus, M., Gebbia, M., Proctor, M., Cheung-Ong, K., Torres, N., Lissina, E., Miranda, M., Schlecht, U., Suresh, S., Aparicio, A.M., Han, MK, Spear, E.D., Nile, A.H., Duby, G., Zeghouf, M., Kim, M.K., Davis, R.W., Kaiser, C.A., Trimble, W.S., Boutry, M., Cherfils, J., Cummins, C.L., Brown, G.W., Schimmer, A.D., Bankaitis, V.A., Nislow, C., Bader, G.D., Giaever, G. Science, 2014 || IF 31.0 |
Liver x receptors preserve renal glomerular integrity under normoglycemia and in diabetes.
Patel, M., Wang, X.X., Magomedova, L., John, R., Rasheed, A., Santamaria, H., Wang, W., Tsai, R., Qiu, L., Orellana, A., Advani, A., Levi, M., and Cummins, C.L.* Diabetologia, 2014 || IF 6.5 |
Vitamin D receptor activation down-regulates the small heterodimer partner and increases Cyp7a1 to lower cholesterol.
Chow, E.C., Magomedova, L., Quach, H.P‡, Patel, R.‡, Durk, M.R., Fan, J., Maeng, H.J. Irondi, K., Anakk, S., Moore, D.D., Cummins, C.L.† and Pang, K.S.† †, ‡ contributed equally Gastroenterology, 2014 || IF 12.8 |
Induction of p-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells.
Chan, G.N., Patel, R., Cummins, C.L. and Bendayan, R.B. Antimicrobial Agents and Chemotherapy, 2013 || IF 4.6 |
Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin-Induced Diabetes
Hazra, S. ‡, Rasheed, A. ‡, Bhatwadekar, A, Wang, X., Yan, Y., Patel, M., Caballero, S., Magomedova, L., Solis, N., Thinschmidt, J., Verma, A., Li, Q., Levi, M., Cummins, C.L.*, and Grant, M.B.* ‡ contributed equally; *co-corresponding authors Diabetes, 2012 || IF 7.9 |
A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
Wollam J., Magner, D.B., Magomedova, L., Rass, E., Shen,Y., Rottiers,V., Habermann, B., Cummins, C.L. and Antebi, A. PLOS Biology, 2012 || IF 12.7 |
Lecithin:cholesterol acetyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.
Hager, L., Li L., Pun, H., Liu, L., Hossain, M.A., Maguire, G.F., Naples, M., Baker, C., Magomedova, L., Tam, J., Adeli, K., Cummins, C.L., Connelly P.W., and Ng, D.S. Journal of Biological Chemistry, 2012 || IF 4.7 |
Dafadine inhibits DAF-9 to promote dauer-formation and longevity of Caenorhabditis elegans.
Luciani, G.M., Magomedova, L., Puckrin, R., Urbanus, M.L., Wallace, I.M., Giaever, G., Nislow, C., Cummins, C. L.* and Roy, P.J.*
Nature Chemical Biology, 2011 || IF 12.9
Luciani, G.M., Magomedova, L., Puckrin, R., Urbanus, M.L., Wallace, I.M., Giaever, G., Nislow, C., Cummins, C. L.* and Roy, P.J.*
Nature Chemical Biology, 2011 || IF 12.9
Compound prioritization methods increase rates of chemical probe discovery in model organisms.
Wallace, I.M., Urbanus, M.L., Luciani, G.M., Burns, A.R., Han, M., Wang, H., Arora, K. Heisler, L.E., Proctor, M., St. Onge, R.P., Roemer, T., Roy, P.J., Cummins, C.L., Bader, G.D., Nislow, C., Giaver, G.
Chemistry & Biology, 2011 || IF 6.2
Wallace, I.M., Urbanus, M.L., Luciani, G.M., Burns, A.R., Han, M., Wang, H., Arora, K. Heisler, L.E., Proctor, M., St. Onge, R.P., Roemer, T., Roy, P.J., Cummins, C.L., Bader, G.D., Nislow, C., Giaver, G.
Chemistry & Biology, 2011 || IF 6.2
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
Wollam, J., Magomedova, L., Magner, D.B., Shen, Y., Rottiers, V., Motola, D.L., Mangelsdorf, D.J., Cummins, C.L., and Antebi, A.
Aging Cell, 2011 || IF 5.7
Wollam, J., Magomedova, L., Magner, D.B., Shen, Y., Rottiers, V., Motola, D.L., Mangelsdorf, D.J., Cummins, C.L., and Antebi, A.
Aging Cell, 2011 || IF 5.7
1Alpha,25-Dihydroxyvitamin D3 upregulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
Chow, E.C., Durk, M.R., Cummins, C.L., Pang, K.S.
Journal of Pharmacology and Experimental Therapeutics, 2011 || 3.9
Chow, E.C., Durk, M.R., Cummins, C.L., Pang, K.S.
Journal of Pharmacology and Experimental Therapeutics, 2011 || 3.9
Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells.
Chan, G.N., Hoque, M.T., Cummins, C.L., Bendayan, R.
Journal of Neurochemistry, 2011 || IF 4.0
Chan, G.N., Hoque, M.T., Cummins, C.L., Bendayan, R.
Journal of Neurochemistry, 2011 || IF 4.0
LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.
Patel, R., Patel, M., Tsai, R., Lin, V., Bookout, A.L., Zhang, Y., Magomedova, L., Li, T., Chan, J.F., Budd, C., Mangelsdorf, D.J., and Cummins, C.L.*
Journal of Clinical Investigation, 2011 || 12.8
Patel, R., Patel, M., Tsai, R., Lin, V., Bookout, A.L., Zhang, Y., Magomedova, L., Li, T., Chan, J.F., Budd, C., Mangelsdorf, D.J., and Cummins, C.L.*
Journal of Clinical Investigation, 2011 || 12.8
AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids.
Schmidt, D.R., Schmidt, S., Holmstrom, S.R., Makishima, M., Yu, R.T., Cummins C.L., Mangelsdorf D.J., Kliewer, S.A.
Journal of Biological Chemistry, 2011 || IF 4.7
Schmidt, D.R., Schmidt, S., Holmstrom, S.R., Makishima, M., Yu, R.T., Cummins C.L., Mangelsdorf D.J., Kliewer, S.A.
Journal of Biological Chemistry, 2011 || IF 4.7
Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism.
Gottschalk, S., Cummins, C.L., Leibfritz, D., Christians, U., Benet, L.Z., Serkova, N.J.
Neurotoxicology, 2011 || IF 2.7
Gottschalk, S., Cummins, C.L., Leibfritz, D., Christians, U., Benet, L.Z., Serkova, N.J.
Neurotoxicology, 2011 || IF 2.7
Liver X receptors as therapeutic targets for managing cholesterol: Implications for atherosclerosis and other inflammatory conditions.
Zhang, Y., Chan, J.F. and Cummins, C. L.*
Journal of Clinical Lipidology, 2009 || IF 0.9
Zhang, Y., Chan, J.F. and Cummins, C. L.*
Journal of Clinical Lipidology, 2009 || IF 0.9
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.
Sharma, K. K., Wang, Z., Motola, D. L., Cummins, C. L., Mangelsdorf, D. J., and Auchus, R. J.
Molecular Endocrinology, 2009 || IF 4.8
Sharma, K. K., Wang, Z., Motola, D. L., Cummins, C. L., Mangelsdorf, D. J., and Auchus, R. J.
Molecular Endocrinology, 2009 || IF 4.8
Identification and quantitation of sorbitol-based nuclear clarifying agents extracted from common laboratory and consumer plasticware made of polypropylene.
McDonald, J. G., Cummins, C. L., Barkley, R. M., Thompson, B. M. and Lincoln, H. A.
Analytical Chemistry, 2008 || IF 5.7
McDonald, J. G., Cummins, C. L., Barkley, R. M., Thompson, B. M. and Lincoln, H. A.
Analytical Chemistry, 2008 || IF 5.7
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
Lee, Y.K., Schmidt, D. R., Cummins, C. L., Choi, M., Peng, L., Zhang, Y., Goodwin, B., Hammer, R.E., Mangelsdorf, D. J. and Kliewer, S. A.
Molecular Endocrinology, 2008 || IF 4.8
Lee, Y.K., Schmidt, D. R., Cummins, C. L., Choi, M., Peng, L., Zhang, Y., Goodwin, B., Hammer, R.E., Mangelsdorf, D. J. and Kliewer, S. A.
Molecular Endocrinology, 2008 || IF 4.8
Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.
Katona, B. W., Cummins, C. L., Ferguson, A. D., Li, T., Schmidt, D. R., Mangelsdorf, D. J. and Covey, D. F.
Journal of Medicinal Chemistry, 2007 || IF 5.6
Katona, B. W., Cummins, C. L., Ferguson, A. D., Li, T., Schmidt, D. R., Mangelsdorf, D. J. and Covey, D. F.
Journal of Medicinal Chemistry, 2007 || IF 5.6
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
Umetani, M., Domoto, H., Gormley, A. K., Yuhanna, I.S., Cummins, C. L., Javitt, N. B., Korach, K. S., Shaul, P. W., Mangelsdorf, D. J.
Nature Medicine, 2007 || IF 24.3
Umetani, M., Domoto, H., Gormley, A. K., Yuhanna, I.S., Cummins, C. L., Javitt, N. B., Korach, K. S., Shaul, P. W., Mangelsdorf, D. J.
Nature Medicine, 2007 || IF 24.3
Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice.
Oz, O. K., Hajibeigi, A., Howard, K., Cummins, C. L., van Abel, M., Bindels, R. J., Word, R. A., Kuro-o, M., Pak, C. Y. and Zerwekh, J. E.
Journal of Bone and Mineral Research, 2007 || IF 6.1
Oz, O. K., Hajibeigi, A., Howard, K., Cummins, C. L., van Abel, M., Bindels, R. J., Word, R. A., Kuro-o, M., Pak, C. Y. and Zerwekh, J. E.
Journal of Bone and Mineral Research, 2007 || IF 6.1
In vivo imaging of FXR activity reveals the ileum as the primary bile acid signaling tissue.
Houten, S. M., Volle, D. H., Cummins, C. L., Mangelsdorf, D. J. and Auwerx, J.
Molecular Endocrinology, 2007 || IF 4.8
Houten, S. M., Volle, D. H., Cummins, C. L., Mangelsdorf, D. J. and Auwerx, J.
Molecular Endocrinology, 2007 || IF 4.8
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.
Gerisch, B., Rottiers, V., Li, D., Motola, D. L., Cummins, C. L., Lehrach, H., Mangelsdorf, D. J., and Antebi, A.
Proceedings of the National Academy of Sciences of the United States of America, 2007 || IF 9.7
Gerisch, B., Rottiers, V., Li, D., Motola, D. L., Cummins, C. L., Lehrach, H., Mangelsdorf, D. J., and Antebi, A.
Proceedings of the National Academy of Sciences of the United States of America, 2007 || IF 9.7
The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice.
Volle, D. H., Duggavathi, R., Magnier, B. C., Houten, S. M., Cummins, C. L., Lobaccaro, J. M., Verhoeven, G., Schoonjans, K., and Auwerx, J.
Genes & Development, 2007 || IF 12.4
Volle, D. H., Duggavathi, R., Magnier, B. C., Houten, S. M., Cummins, C. L., Lobaccaro, J. M., Verhoeven, G., Schoonjans, K., and Auwerx, J.
Genes & Development, 2007 || IF 12.4
Liver X receptors regulate adrenal cholesterol balance.
Cummins, C. L.‡, Volle, D. H. ‡, Zhang, Y., McDonald, J. G., Sion, B., Lefrancois-Martinez, A.-M., Caira F., Veyssiere, G., Mangelsdorf, D. J. † and Lobaccaro, J. M. †
‡,†contributed equally.
Journal of Clinical Investigation, 2006 || IF 12.8
Cummins, C. L.‡, Volle, D. H. ‡, Zhang, Y., McDonald, J. G., Sion, B., Lefrancois-Martinez, A.-M., Caira F., Veyssiere, G., Mangelsdorf, D. J. † and Lobaccaro, J. M. †
‡,†contributed equally.
Journal of Clinical Investigation, 2006 || IF 12.8
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
Rottiers, V. , Motola, D. L., Gerisch, B., Cummins, C. L., Nishiwaki, K., Mangelsdorf, D. J., and Antebi, A.
Developmental Cell, 2006 || IF 12.8
Rottiers, V. , Motola, D. L., Gerisch, B., Cummins, C. L., Nishiwaki, K., Mangelsdorf, D. J., and Antebi, A.
Developmental Cell, 2006 || IF 12.8
Liver X receptors and cholesterol homeostasis: spotlight on the adrenal gland.
Cummins, C. L.* and Mangelsdorf, D. J.
Biochemical Society Transactions, 2006 || IF 2.6
Cummins, C. L.* and Mangelsdorf, D. J.
Biochemical Society Transactions, 2006 || IF 2.6
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Motola, D. L., Cummins, C. L., Rottiers, V., Sharma, K. K., Li, T., Li, Y., Suino-Powell, K., Xu, H. E., Auchus, R. J., Antebi, A., and Mangelsdorf, D. J.
Cell, 2006 || IF 32.0
Motola, D. L., Cummins, C. L., Rottiers, V., Sharma, K. K., Li, T., Li, Y., Suino-Powell, K., Xu, H. E., Auchus, R. J., Antebi, A., and Mangelsdorf, D. J.
Cell, 2006 || IF 32.0
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., Gerard, R. D., Repa, J. J., Mangelsdorf, D. J. and Kliewer, S. A.
Cell Metabolism, 2005 || IF 14.6
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., Gerard, R. D., Repa, J. J., Mangelsdorf, D. J. and Kliewer, S. A.
Cell Metabolism, 2005 || IF 14.6
Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.
Benet, L. Z., Cummins, C. L., and Wu, C.-Y.
International Journal of Pharmaceutics, 2004 || IF 3.5
Benet, L. Z., Cummins, C. L., and Wu, C.-Y.
International Journal of Pharmaceutics, 2004 || IF 3.5
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRα (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.
Volle, D. H., Repa, J. J., Mazur, A., Cummins, C. L., Val, P., Henry-Berger, J., Caira, F., Veyssiere, G., Mangelsdorf, D. J., and Lobacarro, J. M.
Molecular Endocrinology, 2004 || IF 4.8
Volle, D. H., Repa, J. J., Mazur, A., Cummins, C. L., Val, P., Henry-Berger, J., Caira, F., Veyssiere, G., Mangelsdorf, D. J., and Lobacarro, J. M.
Molecular Endocrinology, 2004 || IF 4.8
CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.
Cummins, C. L., Jacobsen, W., Christians U., and Benet, L.Z.
Journal of Pharmacology and Experimental Therapeutics, 2004 || IF 3.9
Cummins, C. L., Jacobsen, W., Christians U., and Benet, L.Z.
Journal of Pharmacology and Experimental Therapeutics, 2004 || IF 3.9
In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: Studies using the rat single-pass intestinal perfusion model.
Cummins, C. L., Salphati, L., Reid, M.J and Benet, L.Z.
Journal of Pharmacology and Experimental Therapeutics, 2003 || IF 3.9
Cummins, C. L., Salphati, L., Reid, M.J and Benet, L.Z.
Journal of Pharmacology and Experimental Therapeutics, 2003 || IF 3.9
Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data.
Benet L. Z., Cummins, C. L. and Wu, C.-Y.
Current Drug Metabolism, 2003 || IF 4.4
Benet L. Z., Cummins, C. L. and Wu, C.-Y.
Current Drug Metabolism, 2003 || IF 4.4
Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).
Unger, M., Holzgrabe, U., Jacobsen, W., Cummins, C. and Benet, L.Z
Planta Medica, 2002 || IF 2.3
Unger, M., Holzgrabe, U., Jacobsen, W., Cummins, C. and Benet, L.Z
Planta Medica, 2002 || IF 2.3
Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein.
Cummins, C. L., Wu, C.-Y. and Benet, L. Z.
Clinical Pharmacology & Therapeutics, 2002 || IF 6.8
Cummins, C. L., Wu, C.-Y. and Benet, L. Z.
Clinical Pharmacology & Therapeutics, 2002 || IF 6.8
Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.
Cummins, C. L., Jacobsen, W. and Benet, L. Z.
Journal of Pharmacology and Experimental Therapeutics, 2002 || IF 3.9
Cummins, C. L., Jacobsen, W. and Benet, L. Z.
Journal of Pharmacology and Experimental Therapeutics, 2002 || IF 3.9
Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).
Flanagan, S. D., Cummins, C. L., Susanto, M., Liu, X., Takahashi, L. H., and Benet, L. Z.
Pharmacology, 2002 || IF 1.6
Flanagan, S. D., Cummins, C. L., Susanto, M., Liu, X., Takahashi, L. H., and Benet, L. Z.
Pharmacology, 2002 || IF 1.6
The drug-efflux metabolism alliance: biochemical aspects.
Benet, L. Z. and Cummins, C. L.
Advanced Drug Delivery Reviews, 2001 || IF 12.9
Benet, L. Z. and Cummins, C. L.
Advanced Drug Delivery Reviews, 2001 || IF 12.9
Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1 and MRP2) in CYP3A4-transfected caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.
Cummins, C. L., Mangravite, L. M. and Benet, L. Z.
Pharmaceutical Research, 2001 || IF 4.7
Cummins, C. L., Mangravite, L. M. and Benet, L. Z.
Pharmaceutical Research, 2001 || IF 4.7
Determination of p-aminosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity.
Cummins, C. L., O’Neil, W. M., Soo, E. C., Lloyd, D. K., and Wainer, I. W.
Journal of Chromatography B, 1997 || IF 2.5
Cummins, C. L., O’Neil, W. M., Soo, E. C., Lloyd, D. K., and Wainer, I. W.
Journal of Chromatography B, 1997 || IF 2.5